[While I can accept that, he also said that Sinemet doesn't work for everyone???? That statement totally stumped me as I don't recall anyone posting that Sinemet doesn't help.

Could anyone enlighten me if this is the case. I'd really like some insight.]

For 8 years I have had most of the classic pd symptoms as well as a diagnosis of pd from five different neurologists/MDS. Been on and off sinemet for 4 years (and most recently sinemet and requip). Haven't noticed any effects positive or negative other than mild nausea and sleepiness, but definitely no offs or ons. Would be delighted to find something that provided some symptomatic relief. So far it hasn't been carbidopa/levodopa. There must be certain non-dopamine responsive forms of this idiosyncratic condition.