I'm very excited to hear this interesting news. From my 23andMe testing, I've been aware of the MTHFR mutation (which I do have) and folic acid issue for a long time and still take methycobalamin B12 and methylfolate. My PD has seemed to progress more slowly than others, but I take other steps as well (exercise, etc.). Problem is, I've never found any reliable guidance about exactly how much to take. Seems there's no valid research to support how to supplement, and there may be a serious problem with "overmethylation" if you get it wrong. I've seen lots of dubious opinions, but no valid science to guide us. My doctor tested me and said my B12 & folate levels were fine, but some so-called "experts" online claim that you can't rely on those tests, but offer no specific alternatives. Anybody have any good reliable sources on these issues?