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Originally Posted by mrsD
Effexor is the first SNRI out.... Cymbalta is similar. The only difference is that Lilly did studies on pain...and Wyeth did not. It is the studies that the FDA then allows for certain pain conditions. But Effexor should work also. The "mixed" norepi/serotonin reuptake inhibitors work best in the brain pain loop.
Savella is also similar but has stronger norepi reuptake features of the 3. Many people cannot tolerate Savella, and drop off it.
It was mainly targeting fibro patients. It was available first in other countries, then came here later, after the other two. Cymbalta is going generic and may have already done so. There will be less push for it then. We may see more Savella posts in the near future therefore.
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I was thinking that if norepi/serotonin reuptake helps with the pain, maybe gabapentin can be tapered. my only reservation to taking the anti-depressants for the long haul is --- my mother in law and cousin in law who are both taking antidepressants for the longest time were sick arguably due to the long termed use of anti-depressants. My mother-in-law has problems with falling without no reason. Sometimes she cannot get up. My cousin-in-law had severe kidney problems because she stopped peeing. When asked, she said she could not feel any urge. The doctor said that her organ stopped communicating to her brain.