Quote:
Originally Posted by soccertese
http://www.plosone.org/article/info%...l.pone.0012728
lewy bodies in the gut were according to this article first reported in 1984. they have found lewy bodies in salivary glands, skin tissue, i imagine other places.
so pd affects more than the substantia nigra, that's been known for years. pd symptoms might be the major visible affect because there are so few cells in the substantia nigra and the produce something so essential, dopamine. every neuron there is precious! sounds kind of like "monty python".
what happens when you create neurons from skin cells from someone who has pd do they develop lewy bodies outside the body, i.e., in culture?
http://www.eurostemcell.org/factshee...tem-cells-help
NIH pd page, lot's of info.
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Thanks for the links. The first one discusses Braak's suggestion:
"Braak and coworkers have postulated that the ENS is affected early by Lewy pathology during the course of PD, even before the pathology is apparent in the substantia nigra. This suggests that the ENS heralds the onset of a pathological process that further spreads to the CNS via autonomic innervation of the gut."
The question still left unanswered is whether the PD starts in the gut or the brain. Braak suggests the gut gets it first but the jury is still out on that. I am hoping it starts in the gut. This would be huge if true as it would give a starting place to focus on to stop PD there if possible!