My spouse and I both have P.D. I have been taking Sinemet and Requip since dsx 2003. I have had a good response to meds but have suffered with dystonia. He was dsx 2006, started on Sinemet but after a couple of years started having side effects, dyskinesia, dry heaves. He decided to try the Dr. Hinz amino acid treatment. The first year seemed not too bad, mixing tyrosine and D5 powders as well as an assortment of supplements in cap form. Second year has been downhill, not getting much "on" time. Freezing has caused problems, not going out much so losing social contact, not enough energy to exercise so losing muscle tone. I feel it is time to make a change but not sure what he would be able to tolerate. Would it be advisable to mix the two treatment, maybe add an agonist to the amino acid treatment? Anyone out there who has tried changing treatments with suggestions would be appreciated. We are not sure what to do next but a change is in order before he loses any more ground.