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Old 05-26-2007, 05:27 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb Jarrett...

I would get some tests done.

Blood tests/urine tests for zinc. And perhaps a hair test too (it will show if long term issues exist for you). I would also suggest a zinc/copper ratio.
Elevated zinc levels are not typical, and doctors do not look for them. Elevated copper occurs in Wilson's disease (a genetic liver disorder).

I found another legal website..unfortunately no new information there yet:
http://www.schmidtandclark.com/Dentures/

This article has 3 accounts of zinc overuse. One man ATE a tube of PolyGrip a day...ate and swallowed excess, I guess because he liked it?

http://www.medscape.com/viewarticle/497023_1
Quote:
Based on our review of the bone marrow biopsy specimen, additional laboratory testing was obtained, which revealed serum copper levels below the detectable range, extremely low ceruloplasmin levels, and high zinc levels (Table 1). The patient was asked further about possible zinc ingestion, and it was determined that he had been consuming an entire tube (68 g) of PoliGrip denture cream (containing polymethyvinylether maleic acid calcium-zinc salt) daily for the past 4 to 5 years. The patient was using the denture adhesive for his dentures and additionally eating "pellets" of it from the tube. The patient was advised to stop ingesting the denture cream, and copper sulfate supplementation was initiated. Approximately 3 weeks after the initiation of treatment, the patient's serum copper levels increased to 20 µg/dL (3.1 µmol/L), and his hematologic values normalized completely (hemoglobin level, 13.0 [130 g/dL]; hematocrit, 39.9 [0.40]; WBC count, 7,900/µL [7.9 × 109/L]). However, the neuropathy showed no improvement.
Eating the paste would place the zinc in the small intestine where the active transporters are.
The second case was taking 600mg a day of zinc...and had no neuropathy. (he was young)

The discussion of low copper induced by zinc ingestion is on page 5. The paper is too long to copy here...but joining Medscape is free:
http://www.medscape.com/viewarticle/497023_5
Quote:
Idiopathic hyperzincemia and hypocupremia associated with extensive central nervous system demyelination, similar to that seen in case 1, recently was reported for the first time.[37] Furthermore, irreversible demyelination has been reported even after copper levels were stabilized through supplementation, although serum zinc levels remained high (unknown cause). In addition, 2 previous descriptions of patients with copper deficiency and concomitant severe progressive peripheral neuropathy have been reported.[15,36] In both of these cases, copper supplementation improved the hematologic symptoms; however, the neuropathies were irreversible.
So it appears to be a low copper issue as well. Very low copper, induced by the excess zinc. There is mention in this article on page 5, certain drugs used (not common) and alcohol may be contributory to the low copper effects on the blood system.

And this article does state, that these are not common occurances. I suggest interested posters here read the whole 5 pages to get a full understanding of this situation.
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