there is a major interaction between Tramadol and SSRI antidepressants.
This link is for Tramadol + Cymbalta:
http://www.drugs.com/interactions-ch...221-0,949-2273
Considered MAJOR...
Taking SSRIs with OTC medications with Dextromethorphan in them also is not recommended. This may result in too much serotonin actions too.
Tramadol has some antidepressant actions in it, but they are mild.
But combined with other drugs that increase serotonin, this may be contributory to serotonin syndrome.
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Weezie looking at petunias 8.25.2017
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