My PN was the worst over 30 yrs ago....none of these drugs were available then... except for Elavil and opiates.

My PN improved considerably with treatment for my low thyroid.

I do have arthritis too, and use 1/2 to 1 tramadol 50mg very seldom at night, if things are too overwhelming for me.

But I prefer topical products over oral today. Salonpas patches (arthritis), Lidoderm RX patches severe nerve issues, Biofreeze for burning (not frequent anymore--- avoidance of potatoes fixed that), and magnets for nighttime pain.

I never used the new SSRI drugs, or gabapentin/Lyrica, or opiates. (I had opiates in the hospital for my C-section, and that was the only time).

I have pre-diabetes now, so sometimes my feet flare up, but not terribly. I've learned to live it all, for the most part.

I am currently on a new gluten free attempt...since my GI issues have been more active than usual. I also have congenital malrotation of the GI tract, and hereditary angioedema. So my GI problems are far and away the worst now than ever!