Exercise and Sport Sciences Reviews
MRI Reveals Brain Abnormalities in Drug-naive Parkinson's Disease

Peggy J. Planetta, Nikolaus R. McFarland, Michael S. Okun, David E. Vaillancourt
Disclosures

Exerc Sport Sci Rev. 2014;42(1)



Abstract and Introduction
DTI Reveals Microstructural Brain Abnormalities in De Novo PD
Bold fMRI in Healthy Adults and De Novo PD During Motor Tasks
Summary and Future Directions



Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.