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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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So a reasonable hypothesis...
...might be that one of a number of factors leading to PD is that our individual responses to stress result in varied amounts of hormonal release which lead to individualized disruption of the BBB.
Toxins find their way from the gut by way of its similarly compromised barrier into the bloodstream and thence into the brain. Among those toxins are bacterial LPS as well as metals, pesticides, etc.
LPS potentiates the toxicity of mercury, rotenone, etc.
In previously sensitized individuals, LPS activates the microglia (brain immune cells) leading to over-reaction and self harm.
One of the higher concentrations of microglia is in the substantia nigra.
This is not the whole tapestry, but seems reasonable as one of the primary threads.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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