I agree that there is interest in the methylation cycle and its relationship with PD, and, ultimately you may be correct that it will lead to new treatments. However, that is much different than stating that new research strongly suggests that PD can be treated by fixing this. The research on the relationship between PD risk and problems with methylation is decades old. What would interest me, and probably many other members, would be if you can provide current research which gives evidence that controlling the cycle can be interventional (slow progression) or provide symptomatic relief. I certainly hope this can be found and, again, it's one of the reasons I'm interested in the inosine research. I was just unaware of any methylation research that supports your statements and would like to read it if available.