Lisa, Did your doctors test you for the TPMT enzyme BEFORE they put you on Imuran?

http://www.southend.nhs.uk/pathology...l-transferase/

"TPMT provides the major catabolic pathway for these drugs. If the enzyme is absent in the patient there will be an 'over-dosing' effect, frequently resulting in severe bone marrow depression, also nausea."

http://www.rheumatology.org/Practice...rine_(Imuran)/

I think over-suppression of your immune system, even if you have the TMPT enzyme, is also a concern. More is not always better.

Call your prescribing doctor!

Annie