Quote:
Originally Posted by AnnieB3
Lisa, Did your doctors test you for the TPMT enzyme BEFORE they put you on Imuran?
http://www.southend.nhs.uk/pathology...l-transferase/
"TPMT provides the major catabolic pathway for these drugs. If the enzyme is absent in the patient there will be an 'over-dosing' effect, frequently resulting in severe bone marrow depression, also nausea."
http://www.rheumatology.org/Practice...rine_(Imuran)/
I think over-suppression of your immune system, even if you have the TMPT enzyme, is also a concern. More is not always better.
Call your prescribing doctor!
Annie |
Yeah my neuro did that TPMT test before he put me on imuran. I actuality was doing really good kn 60/20 alternate days of prednisone back kn the fall. Now since the Prednisone drop. He tried having me alternate 50/0 but I couldn't do it. Got too weak. So I started taking 10mg prednisone and it has helped just I get thews periods of time where my temp rises to 99° and I get nauseated and sick feeling along with weakness. I failed the strength test miserbly last neuro appointment so he ordered a IVIG which still waiting for the insurance to authorize. I tell ya if its not 1 thong its another.