Yes, any stress on the body, as Juanitad said, can adversely affect MG. So many things can.

Examples of things that can affect MG: Stress, not enough sleep, not enough protein in the diet, lack of B12 (we need it to make acetylcholine), extremes of heat and cold, too much potassium or magnesium, nightshade foods (potato, tomato, peppers, nicotine, eggplant, etc.) and caffeine are cholinesterase inhibitors like Mestinon and MIGHT make you better or worse, infections (viral or bacterial), surgery, crying, not resting enough in between activities, too much nonstop activity, not enough hydration (water intake), an overactive or underactive thyroid or other endocrine problems, allergies, food sensitivities, and so many other things that might contribute to an imbalance in your immune system.

Mestinon doesn't necessarily "fix" facial and speech issues. If you are not getting better, you should make a call to your neuro. You might need to consider additional medications that address the immune issue (antibodies attacking your tissues). Although, what you do is your choice!

MGers need to balance activity with rest. Mestinon only goes so far. Even if you're on other drugs, having MG is still about being sensible. It sucks to have to reduce activities or alternate them with rest but it's a smart thing to do.

The more you do, as Unsure said, can push your MG too far to the more severe state. The worse MG gets, the longer it takes to recover. It's best to maintain an even strain.

I really think you should call your doctor. Ask him/her about the Mestinon dose amount and the spacing between doses. Maybe you guys can figure something out that works better for you.

I hope you feel better soon. Keep asking questions. This is a very unpredictable and rather frustrating disease!

Annie