Quote:
Originally Posted by mrsD
An analogue is not necessarily an agonist.
In fact the Benzos used to be called GABA agonists, but they are now considered more as allied agonists.
Gabapentin was initially put on the market when at that time its mechanism of action was "not known".
http://www.rxlist.com/neurontin-drug...armacology.htm
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Benzodiazepines: Xanax:
http://en.wikipedia.org/wiki/Alprazolam
So while gabapentin was marketed to be a useful seizure control drug, it is not often used for that... it is used for chronic pain and allodynia. The Lyrica cousin was thought to be useful for anxiety but that didn't turn out to be the case. Lyrica however was given a IV (FOUR) controlled class rating, just in case.
Benzos are useful for the postictyl state following a seizure (usually Valium --diazepam is used). They help to prevent further cascading ones from happening and causing status epilepticus:
http://www.ncemi.org/cse/cse0104.htm
So the Benzos share the antiseizure actions for people that other antiseizure drugs do. Mostly they are add ons and not primary. |
I was referring to xanax. I didn't take one last night and hardly slept and my nerves are on fire today. My stomach seizure feelings have been better though. What you say is sure interesting. I read that pregabalin is also a gaba enhancer. I couldn't find any info on here about it used for nueropathy though.
I don't know if I made it clear here but I have been diagnosed with MALS and have talked to 2 surgeons that think the surgery may not help me. The nueropathy I have is directly related to my stomach though. Sometimes I feel fine until I eat then my nueropathy flares up, feet cramp up twitches all over. Other times I will be in lots of pain and eat and it will all go away. I woke up feeling horrible today, Ate a big (for me) lunch and have been much happier since. Also if I take anything for my stomach (ppi, stomach supplements such as pepzin or any supplement or food that is hard on the stomach) my nerves flare up like crazy. I took cymbalta and i made nerves really bad and made my stomach worse. I think I am going to have the surgery cause its the only way to know if it will help or not.
So my take is I respond to Gaba enhancing drugs or anti convulsants like xanax. What other gaba enhancing drugs are there?