your're welcome.

kind of posted that for the newly diagnosed who can't tolerate agonists or aren't getting adequate symptom relief won't be so scared to try l-dopa.

for someone like me, whose insurance won't pay anything for neupro or name brand requip xl and is just taking a combo of sinemet and sinemet-cr because can't tolerate mirapex or requip, it certainly isn't a "honeymoon" anymore after 12 years because of the short sinemet half and sudden wearing off. and having to be sure i don't eat too much protein within an hr of a dose, a cup of cooked lentils will negate a dose. so at least for me sinemet kind of controls my life much more than a long lasting agonist would. hoping the nasal l-dopa if it gets approved and i can afford it will smooth out the doseages and make treating sudden wearing off a few minute fix. might just be pie in the sky.

that's why agonists were developed, long half life and i assume no protein interference.