There is a limit which most doctor feel is safe and do not have to worry too much about cholinergistic crisis. I think I read somewhere about 540 per day seemed a max safe number. I was up to 660 a day and my neuro did not want to go any higher and ordered IVIG. After IVIG I was able to decrease mestinon again. Many on this site take higher doses which I think are more carefully monitored to ensure they can safely take it. It all depends on how severe the MG and how well you tolerate Mestinon and how well it improved you. I would not play around too much with the dose without talking to your neuro.


kathie