I take a low dose of anti-depressant (Prothiaden aka Dothep) in the evening to help with 'burning' legs/feet, and I take a small dose of Topamax morning and night, which is an anti-epileptic to help with getting correct pain signals and so on to my legs. The doc put me on that because I had a series of falls over a fairly short period - and thankfully (or coincidentally - who knows), I haven't had a fall since. It does help some. If I go without for a while, I can certainly feel it getting much, much worse; I am also less stable for some reason.