from 2012 -
http://www.biomedcentral.com/1471-244X/12/29
Altered monocyte activation markers in Tourette’s syndrome: a case–control study
Judith Matz, Daniela L Krause, Sandra Dehning, Michael Riedel, Rudolf Gruber, Markus J Schwarz and Norbert Müller
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The limited size of our sample—in particular with respect to interfering variables such as age, medication and co-morbidity—means that further intense research regarding the role of inflammation, infection, and the immune system in TS is required. Particularly functional tests and the analysis of genetic polymorphisms that encode for inflammatory cytokines or sCD14 would be of interest.
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Conclusions
The present findings point to monocyte dysregulation in TS. This possible dysbalance in innate immunity could lead to a higher susceptibility to infectious agents and a chronically latent inflammatory state in TS or could predispose to autoimmunity.
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BMC Psychiatry 2012, 12:29
doi:10.1186/1471-244X-12-29
This is an Open Access article distributed under the terms of the Creative Commons Attribution License