Hi, Ron. Welcome.

Please ask your primary doctor to test you for a B12 deficiency. When you experience twitching in your hands and feet, it could be a B12 deficiency.

It could also be a circulatory issue, but that's not as likely.

Because you're on Prednisone, you might have a calcium or Vitamin D deficiency, and those two things can cause twitching.

Also, if you are retaining fluids on Pred, that can give you an imbalance of electrolytes as well.

A high school friend of mine died of ALS. It's scary because most people die of it. They are finding different forms of ALS, some that are faster and some that aren't. There are usually other reasons for muscle twitches of fasciculations.

Ditto on what Limpy said.

Annie