Oh yes!!!! I feel like I got my face botoxed starting 3 days premenstral... it's awful! but hey - no need to track my cycle or anything, as I always can tell due to my symptoms when I'm about to start - it's like clockwork 3 days before. and usually 2 days into it my symptoms are much worse.. and then things start to get better... I still flare like that even on IVIG.. it's great when IVIG is timed to really kick in at its best during that time of month... fun times!