What are we talking about, Annie?

Are you saying methylcobalamin is not an improvement for people today? Or are you saying that sublingual works and oral doesn't?

There are many studies comparing all 3 modes of treatment, by the response of patients. And all three gave improvements that are very similar. When you do sublingual you dissolve the lozenge in saliva which is then swallowed. So if you do sublingual and that is your choice, you should do it on an empty stomach so any you swallow will also be absorbed.

It doesn't really matter how you take the methylB12, but it does matter that the methylB12 should be done.

The rate of absorption has been measured by blood tests in volunteers...and that link is on my thread. 1000mcg orally translated to 13mcg absorption into the blood.

I've spent years looking for confirmation that sublinguals really deliver, but never found it. Now that methyB12 is so inexpensive, and is still sold for those who want to do sublingual or who want to chew them up and swallow, there is no reason to continue looking.

For decades it was not understood that B12 can passively pass thru the intestinal walls without intrinsic factor. But now we know it can. That is why the massive dose... 1000 to 5000mcg to get 13 or a few more mcg into the body. Since only 2-4mcg are the RDA, that is still 3 times the amount needed for us.

It might interest readers here that from an injection 1000mcg, only 150mcg were found in the test study.

http://www.ncbi.nlm.nih.gov/pmc/arti...able/T1/#TF1-4

What is changing rapidly is the data regarding the MTHFR polymorphism genetic errors. At first it was suggested at 10%, but now I am seeing 40% as a possible higher figure. The last person on these boards was a doctor who specialized in this who posted about 3 yrs ago, that 30% was showing up in studies.

Also showing up is that about 40% in US are low in B12. This is because of chronic use of acid blocking drugs and the use of metformin for type II diabetes. Birth control pills, some antiretrovirals, and long term use of antibiotics also inhibit B12 absorption. So today this is a growing problem with many people.

Many people on our PN board use B12, and many are using methylB12 and swallowing it.

Because many companies still make it in that form you can choose to keep under the tongue, you can still choose to do it that way.
Just don't do it with food in your stomach, because you will swallow most of it. The success of oral use is in how you take it....it must be taken on an empty stomach with no food following for about an hour after.
Chemically B12 is a huge molecule, and huge water soluble molecules don't cross the membranes of the mouth easily or quickly.