Great discussion, guys.
Limpy, When you mentioned the numbness and tingling, as did others, that's why I started this thread. So many people are B12 deficient and don't even know it. And it's uniquely important to MGers since we need B12 to make acetylcholine. I hope you will get tested, but, as Mrs D said, you need to be off of B12 for a while beforehand.
Yeah, Rach is a boffin from way back.
And her situation is an example of how much can go wrong when the autonomic nervous system is out of whack. She has POTS, and that can affect other systems in the body.
Jana, What is ironic is that both not enough and too much acetylcholine might trigger a migraine. I don't have migraines anymore. I took the triggers out of my diet (MSG, as in tomatoes which are a nightshade), stay away from bright lights, and now I have enough acetylcholine. Migraines run in my family and I honestly believe that they are related to some unknown genetic channelopathy. You could try taking some chewable calcium the next time you have a migraine. Benadryl might work, too, but not if you're sensitive to it, as some MGers are!!
The point I was trying to make is that in our little biochemical factory called the body, one little kink—no matter how
seemingly insignificant—can throw the rest of the cogs off. This is how disease states begin.
Years ago, I did a bunch of research for a friend of mine with chronic migraines. Acetylcholine does play a role in them, as can other neurotransmitters. Why do you think they now recommend Botox for migraines?
This is a complex topic, because the biochemical processes in the body are all interrelated.
Below are some pearls that relate to MG and are interesting to contemplate. I don't have the energy right now to do a bunch of research. The thread I put up a while ago about this might still be here. Found it.
http://neurotalk.psychcentral.com/sh...d.php?t=182507
Migraines and neurotransmitters.
If you want to know more about migraines, simply google "migraines acetylcholine."
Scroll up to see the start of the chapter.
http://books.google.com/books?id=X4l...holine&f=false
The neurotransmitters and more.
http://www.moodocean.co.uk/html/neurotransmitters.html
http://umm.edu/health/medical/report...aine-headaches
Channelopathies
MG is a channelopathy.
http://www.bmj.com/rapid-response/20...hannelopathies
http://www.pps.org.pk/PJP/6-1/Amina.pdf
http://brain.oxfordjournals.org/content/125/6/1177.long
http://link.springer.com/article/10.....01.007#page-1
Paper based on studies about CFS being a neurological channelopathy.
http://phoenixrising.me/research-2/t...syndrome-mecfs