I'm getting very good improvement with neuropathy on my feet with Kerasal,NeuroCream. My discomfort is bad tingling, which when I don't treat, turns into a burning feeling. Although Im unsure if my pain is as severe as yours, this cream began working in like two days. I put it on twice a day on the bottom of my foot only. Kerasal makes many foot creams; only the Neurocream works.