I have had PN since January 1994. Fast forward to 2012, and out of the blue my sensory neuropathy goes from manageable to off the charts painful, with a dramatic increase in fasciculation.

What might cause my course to take such a dramatic turn so much later? The only thing I can think of is stress, which makes it markedly worse.

Should I be demanding a thorough workup again after all these years? Any new diagnostics available now that were not available then?

I did have a skin biopsy last year that showed reduced nerve density (as I expected).

All tests negative in 1994 except for:

• Elevated spinal fluid protein (92)
  • Elevated CSF IgG and Albumin
  • Elevated CSF synthesis rate
  • Serum immunoelectrophoresis notable for modest polyclonal increase in immunoglobulins
  • One oligoclonal band (within normal limits?)

Does the one oligoclonal band in the CSF mean anything?

Has anyone had success with a spinal pain pump?

I just don't know how much longer I can carry on suffering like this. Please offer an opinion on where I go medically.

Thanks in advance for sharing your viewpoint