Thread: Is this PN?
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Old 05-28-2007, 06:53 AM
glenntaj glenntaj is offline
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Join Date: Aug 2006
Location: Queens, NY
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glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default And I do highly recommend--

--the Liza Jane spreadsheets available at www.lizajane.org.

This is probably the most comprehensive listing of tests for neuropathic symptomology yet devised, and it functions not only as a alisting but as a tracking chart over time.

Regarding the diabetic possibility, testing of fasting blood sugar and hemoglobin A1c is not enough--many people show impaired glucose tolerance only reactively, so it is a good idea to get at least a three-hour glucose tolerance test with readings taken every half-hour. (I also recommend they be done with concurrent insulin levels, to see the rise/fall of glucose in response to insulin production and how much insulin is needed to cause the various shifts--good way to determine insulin resistance/metabolic syndrome).

It has become increasingly recognized that many can show signs of neuropathy before being diagnosed with frank diabetes, even at levels of "only" impaired tolerance:

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/q...d_AbstractPlus

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

http://care.diabetesjournals.org/cgi...full/24/8/1448

http://www.jabfm.org/cgi/reprint/17/2/127.pdf


I could go on, but you get the idea.

The most "classic" presentation of neuropathy is for is to show up in feet first, due to the "die back" phenomenon of the nerves farthest from the center of the body to be preferentially affected, but this is not characterisitc of all neuropathies. (It is more characteristic of those with ischemic/vascular components--circulation is most easily compromisable in the areas farthest form the heart.) One can get an initial set of symptoms anywhere, and the progression is variable as well.

Investigations into causes of neuropathy--indeed, causes of any neural symptoms--can be long and expensive. Many symptoms of the peripheral symptoms can be exactly mimicked by those of the central nervous system, and it can take a lot of process of elimination to tease these out (if they even can be teased out).

I would start by making sure I recieved ALL test results to this point (always keep your own copies) and compare them to the spreadsheets--see what your values are, and what tests might make sense to add.
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