I started with 1.5, then went to 3 after a few weeks, then went to 4.5 about a month after that. I also take Baclofen to control spasms, Ibuprofen for pain and Modafinal to counter narcoleptic fatigue. This body seems to react poorly to other medications, so I avoid them...or even trying them.

For me, the LDN takes the edge off of symptoms and the times that I have gone off of it for a few days, the body let me know with an increase in symptom intensity.

It is important that LDN be taken as close in time to when you have deep sleep (REM). I usually take mine around 11:00 PM.

Hope that it works for you.

With love, Erika