Grand Magnate
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Join Date: Aug 2006
Posts: 4,440
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Grand Magnate
Join Date: Aug 2006
Posts: 4,440
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Was your father ever "diagnosed" with CMT1A? As far as having large calf muscles but weak, that is normal too with CMT. You do not have to have thin calves, hammer toes, high arches, etc. Your feet can look normal but you can still have CMT. It depends on the muscles that are affected.
CMT symptoms vary greatly even within the same family. If you have EMG/NCV testing that should tell you if you have CMT1 or CMT2 but not the sub type. When the myelin is damaged (CMT1) the nerve impulses are conducted more slowly than normal. If the axon itself is damaged (CMT2) the speed of nerve conduction is almost normal but the strength of the signal is reduced. All forms of CMT are either demylinating or axonal in nature. CMT is a multi-gene disorder and so there are many different genes that cause the disorder. There are over 70 kinds of CMT identified so far. A neurologist who knows CMT should be able to tell if you do indeed have CMT with EMG/NCV testing and whether it is of the most common - CMT1 or CMT2. However, if your father was diagnosed with CMT1A that is what would be in the family.
DNA blood testing is expensive so that is a concern. As I said, EMG/NCV testing should be able to tell you if you do have CMT1 or CMT2.
CMT is progressive no matter what you do. You can have symptoms of CMT that are evident when you are young, old, or in-between. Or you may never have symptoms that are evident but you still have it. No one, not even a doctor, can tell you how you will end up with CMT. Hope you find the answer.
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Kitt
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"It is what it is."
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