Here is one paper from PubMed:
Quote:
Inflammopharmacology. 2004;12(4):373-89.
PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I.
Navab R1, Aingorn H, Fallavollita L, Sallon S, Mechoulam R, Ginsburg I, Vlodavsky I, Brodt P.
Author information
Abstract
The growth factors basic fibroblast growth factor (bFGF) and insulin-like growth factor 1 (IGF-I) have been implicated in the pathophysiology of atherosclerosis and restenosis. The Tibetan herbal preparation PADMA-28 (a mixture of 22 plants which is used as an anti-atherosclerosis agent) was tested for its ability to inhibit the mitogenic activity of bFGF and IGF-I, growth factors involved in restenosis, atherosclerosis and tumour progression. DNA synthesis and proliferation of vascular smooth muscle cells, in response to serum bFGF, thrombin, or combinations thereof, were abrogated in the presence of microgram amounts of both the aqueous and organic, partially purified, extracts of PADMA-28. These fractions also inhibited IGF-I-mediated proliferation, migration and invasion of tumour cells responsive to IGF-I. The inhibition by PADMA 28 was reversible upon removal of the PADMA extracts, indicating that the effects were not related to cell toxicity. These and other properties (i.e., anti-oxidant activity) of PADMA-28 may be responsible for its beneficial effect as an anti-atherosclerotic agent, suggesting that this herbal preparation may have potential applications in the prevention of intimal hyperplasia and arterial stenosis secondary to coronary angioplasty and bypass surgery, as well as in the prevention and treatment of other vascular diseases and tumour growth and metastasis.
PMID:
15901415
[PubMed - indexed for MEDLINE]
|
http://www.ncbi.nlm.nih.gov/pubmed/15901415
and another:
Quote:
Forsch Komplementmed. 2006 Feb;13 Suppl 1:13-7. Epub 2006 Feb 17.
Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall.
Exner M1, Raith M, Holzer G, Gmeiner B, Wagner O, Kapiotis S.
Author information
Abstract
BACKGROUND:
The Tibetan herbal preparation Padma 28 has been shown to act as an anti-atherosclerotic agent in advanced peripheral arterial occlusive disease. We tested the effect of aqueous Padma 28 extracts on both the Creactive protein (CRP) induced expression of the pro-inflammatory cell adhesion molecule E-selectin and the anti-atherosclerotic protective enzyme heme oxygenase- 1 (HO-1) in human aortic endothelial cells.
METHODS AND RESULTS:
According to FACS analysis, quantitative RT-PCR and Western blot, CRP-induced E-selectin expression was completely prevented by aqueous Padma 28 extracts. Additionally, Padma 28 mediated an up to 60-fold upregulation of HO-1 mRNA as measured by quantitative RT-PCR. This upregulation could also be demonstrated on the protein level.
CONCLUSION:
Aqueous extracts of the Tibetan herbal preparation Padma 28 inhibit CRP-induced expression of the inflammatory cell adhesion molecule E-selectin and lead to upregulation of the vascular protective enzyme HO-1 in human aortic endothelial cells. These properties may be responsible for its anti-atherosclerotic effects in peripheral arterial occlusive disease.
PMID:
16582558
[PubMed - indexed for MEDLINE]
|
from
http://www.ncbi.nlm.nih.gov/pubmed/16582558
It appears that this complex mixture of herbs has been around for about a decade. You should be able to find more.
Herbs are always a crap shoot... they are really mini-drugs and as such get put on the market before much can be learned about them. (interactions and other serious body effects can be present like interference with liver metabolism, and thinning of the blood, which are two examples).
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