From a meta-analysis of studies in 2013:
http://www.ncbi.nlm.nih.gov/pubmed/24491883
Quote:
Int J Vitam Nutr Res. 2013;83(2):101-11. doi: 10.1024/0300-9831/a000149.
Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy: a meta-analysis of randomized controlled trials.
Eum S1, Choi HD1, Chang MJ2, Choi HC3, Ko YJ3, Ahn JS3, Shin WG1, Lee JY4.
Author information
Abstract
PURPOSE:
This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN).
METHODS:
A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, compared with placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 % credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR < 1.
RESULTS:
Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300 - 600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10 - 1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 % CrI 0.06 - 0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs.
CONCLUSION:
Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.
KEYWORDS:
chemotherapy, peripheral neuropathy, vitamin E
PMID:
24491883
[PubMed - in process]
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The studies do vacillate back and forth, and readers here should consult their physicians for further advice.
Here is a link from American Cancer Society, and lists what may help with neuropathy from chemo (2013):
http://www.cancer.org/acs/groups/cid...002908-pdf.pdf
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