I believe many MS people prescribed anti-depressants don't give it enough time to work - 6 to 8 weeks of consistent use is mandatory. Everyone wants to see immediate results ... we're only human.

Then, when we don't see results after 8 weeks, we give up. WRONG! Try a different AD. For at least 8 weeks. If that doesn't help, Try a third type!

I know from personal experience. Years ago I was prescribed Paxil by my MS neuro. After 8 weeks there were no changes in my depression. Next I tried Wellbutrin. Another 8 weeks with no improvement.

I tried one more - Effexor. After only 3-4 weeks on Effexor I felt I could make it through a day without crying from little things like not being able to button a blouse, or to pull up my socks. Or to go up three steps. It was nice to actually feel almost "normal" again. Of course I still couldn't do any of those things, but I found a way to accept it was ok that I had limitations and there was always a solution. It was truly "freeing" for me, like taking a BiG load off.

I still cried/cry at appropriate times .. sad movies, hurt and homeless animals, and at Hallmark Card commercials. AD's don't stop one from feeling; they help bring your emotions back to normal. Whatever that is.

It's been around 8 or 9 years now that I've taken my AD. As I continue to progress, (I'm PP and very, very progressed) I know how much difference the Effexor has helped me accept it without crying every day.

msbluis