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Originally Posted by Nebulous
-The compounding pharmacy that I called a couple of days ago didn't think that capsaicin was something they could get though I realize it's not essential.
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Try another compounding pharmacy?
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-When ingested orally it's my understanding that amitryptiline needs to be taken for a while before showing effect. Would this not also apply when administered topically?
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Probably.
ketamine amitriptyline cream turns up some long term studies that suggest that.
One such study
http://sullivan-painresearch.mcgill....noct2005_2.pdf states:
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In a previous pilot trial, we examined the potential
analgesic effects of a topical formulation of a cream
containing 1% amitriptyline and 0.5% ketamine.25 Although
there was no acute treatment effect during the
2-day placebo-controlled part of the trial, in 11 patients
who took part in the 7-day open phase of the trial, there
was a significant analgesic effect by day 3 of treatment,
which continued to increase to day 7. The results of the
open phase trial suggested that a longer treatment period
was necessary to observe a beneficial effect.
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Some of the other studies stated somewhat longer periods.
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