Do you find an obvious differences when getting generic drugs from various manufacturers? Meaning not working as effectively from generic to generic.

I first noticed when I went from brand Vicodin to generic. I had to hunt for a good generic that provided the same pain killing effect and not stomach upset from weird fillers.

I rarely take Ambien but have had a bad spell of health lately. Normally I buy 10 mg and just take 1/2 a pill And I was knocked out for hours. I just got a new generic and the 10 mg barely makes a dent in my sleep. I recently have been using CVS as my local private pharmacy sold out to them.

Do others experience this?

I did find a generic Norco 10/325mg made by Amneal was the best I could find.
thanks diandra