Quote:
Originally Posted by Diandra
Do you find an obvious differences when getting generic drugs from various manufacturers?
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In general, no, but in some very few circumstances,
possibly.
Unlike supplements which are not regulated at all, prescription medications—even generics—are heavily regulated.
Understanding Generic Drugs > Facts about Generic Drugs
Myths and Facts About Generic Drugs - WorstPills.org -
That said,
placebo—and
nocebo—effects can be very powerful and work in unexpected ways,
and there are a LOT of factors, e.g. perception and doubt, just to name two.
Quote:
[T]he placebo effect is no small or insignificant statistical aberration. Estimates of the placebo cure rate range from a low of 15 percent to a high of 72 percent.
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The placebo effect is not deception, fluke, experimenter bias, or statistical anomaly. It is, instead, a product of expectation. The human brain anticipates outcomes, and anticipation produces those outcomes. The placebo effect is self-fulfilling prophecy, and it follows the patterns you'd predict if the brain were, indeed, producing its own desired outcomes.
http://www.psychologytoday.com/blog/...t-how-it-works
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nocebo effect and generic drugs
Is this what you're experiencing? Cuss if I know. It's only one possible explanation, but a very real possibility. No judgment involved or to be inferred. Please don't take it that way!
A few years ago, the formula of oxycontin was changed—allegedly to deter/reduce abuse/overdose—but it coincidentally extended the patent
just as it was about to expire. (Hmmm...
) Chronic pain patients all over the internet were complaining that, despite insistance that the amount of oxycodone (the active ingredient) was the same, the new formulation's efficacy was
not the same—it didn't work as well. Were these people ALL abusers complaining of sour grapes because their favorite drug couldn't be as readily abused anymore? Indubitably some were, but not all; statistically, only a small minority. Was/is the new formulation less efficacious, or is it a case of nocebo effect? I wouldn't know that either.
Doc