Wow I'm sorry to hear you guys have had such bad reactions to Topamax. I take 125 mgs a day (of the generic Topiramate) and I do great with it. But then I've been on it for years for my migraines and probably am accustomed to its effects. The only time I've had a problem with it is when we increased the dose a little last summer. I had zero appetite. Had to force myself to eat. But otherwise Topamax has treated me well.