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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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One part of PD....
....is a reaction of the immune system's defenders in the brain (microglia). While not a true autoimmune response, it appears to be the fatal endpoint of a chain of interacting events. The defenders don't turn "off" as they shold.
Another possible factor is a immune response resulting from cross reaction and ties into Ron's BBB thoughts. The scenario is that inflammation increases the permeability of the barriers at the ut as well as the brain. This allows poorly digested protein fragments known as lectins to penetrate into the system and trigger a true immune response. Unfortunately, segments of the molecular chain forming the lectins are similar to segments making up parts of our own brains. Our immune system then attacks our brain tissues in a case of mistaken identity.
The latter contains more speculation than the former, by the way.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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