i received a major beneficial effect on my rigidity after the first tablet.

give it time, it takes awhile for your body/brain/neurons/dopamine receptors/DNA to adjust and you may have to adjust doseages and timing. line NAN said, everyone is different and since less than 10% of l-dopa actually gets into the brain, just how one's digestive system works can affect how much one needs to take. and you really don't need that much l-dopa to get into your brain on a daily basis so one is having to take a lot more than they really need just so that <10% gets into your brain.

the goal is to get the drug as fast as you can into your blood. so drink at least 6oz. of water with each dose to stimulate stomach emptying and one should try to stay as "regular" as possible, getting backed up slows the digestive system and you want that l-dopa to also get into the small intestine as rapidly as possible which is where it is absorbed.