Oops! I do not know why I switched from the methyl form to the cyano form at some point. Thank you for picking up on that. From what I just read, even without the MTHFR polymorphism issue, the methyl form is synthetic and may not be absorbed.

If I did have the MTHFR polymorphism error, though, would it not show up on my homocysteine test?

In terms of next steps, do you have any other suggestions? Should I pursue lupus? diabetes? fibromyalgia? I just do not understand why now it is getting worse when my regimen has not changed unless it is one of these auto immune diseases. Other than that, stevia toxicity has crossed my mind so I have tried to cut down significantly. Or the linzess causing some kind of absorption issue but nothing comes up for these side effects in any medical searches. Plus I have been on linzess for constipation for almost two years now.