[If you are already taking antidepressants and considering taking supplements containing GABBA You should check with your MD. There is a lot of uncertainty about the possible negative effects of GABBA and other "brain" supplements.

My wife had been recovering from a deep depression when her mother, brother, father, and sister died one at a time over a 4-year period 2006-2010. She was the primary caregiver for each one of them.

She was put on ARMOUR THYROID, TRAZODONE, EFFEXOR, and ABILIFY by her own doctor and her recovery from depression was progressing well when we moved to Florida for the winter.

She was slowly improving and was about 85 % of her normal self when her friend suggested that she see a well- respected doctor who specialized in GABA supplements and might be able to help her complete her recovery. She did see the doctor and he convinced her to try several GABA products (which he sells).

But after about a a month of taking the supplement products she was beginning to suffer an increase Depression symptoms again. The doctor told her to have patience and that she should continue to use the products assuring her that things would get better. But hey didn't get better….. if fact after 2 months her depression symptoms were getting much worse than any she had experienced in the past. At that point, with my urging she stopped taking the supplements. As of today she still has the following depression symptoms:

1. Constant Fatigue, 2. Whole body tremors, 3. loss appetite, 4. constant "head in a vice" aches, 5. chest pressure, 6. confusion, lack of concentration, 7. greatly decreased energy , 8. emotional numbness, 9. a loss of pleasure in everyday activities that she used to enjoy, 10. constant anxiety, 11. lack of sleep, 12. difficulty remembering, 12. excessive worrying, 13. difficulty making decisions, 14. "heavy legs" , and 15. no libido.

Most of these symptoms only happened at a high level after taking the supplements.

I'm not suggesting that the GABA products are the cause of my wife's continuing symptoms listed above. But there seems to be much uncertainty about GABA.

perhaps GABA when combined with one or more antidepressants may have triggered her "crash" She has been off of all Supplements for about 2 months but she still has the above symptoms.

She is still taking ARMOUR THYROID, TRAZODONE, EFFEXOR,and ABILIFY. In addition she is taking. , Vagifem, Prometrium, Estradiol, and DHEA-KETO.. She has been taking these medications for several years without problems. According to her own Doctor Her Sarotonin levels and Thyroid are excellent and her Brain Scan was also fine.

I'm very interested in any ideas and suggestions that may help her particularly in the area of MEDICATIONS. She has already had counseling, and talk therapy sessions with no change.

I will pass along any suggestions to her doctor and to the psychiatrists she will be seeing over the next few weeks. She has already seen one psychiatrist who adjusted some of her meds but after several weeks there had been no change in her condition.