Just started seeing a new rheumatologist, and again despite Johns Hopkins not giving me a diagnosis, the blood work he requested has come back clearly positive for Sjogrens (ANA positive, SSA high, and C-3 low). So I have gone full circle and am back to Sjogrens as the medical cause of my neuropathy, joint pain and fatigue.

This new doctor wants me to start the classic Sjogrens protocol of plaquenil and gabapentin. I am also still on Tramadol, Synthroid and Linzess (newer constipation drug). For the worsening joint pain, he suggested methotrexrate. I declined due to side effects - apparently your liver needs to be monitored and if you get pregnant the fetus will be deformed. Those are a bit scary to me. Instead I am trying out OTC Alleve 2x a day - which is not helping at all yet.

Has anyone tried methotrexrate and if so what were the results/side effects?

Thanks!