Originally Posted by mrsD

Methotrexate may be hard on the stomach over time. ( When it causes too much GI issues, then they move patients to injectable.)
Report any pain or bleeding, or vomiting to the doctor.
Many use it okay, though, but if you have borderline ulcers or chronic gastritis there may be issues.

And it will deplete folic acid...so you need to ask your doctor about what dose you should take with it.

Antirheumatic treatment is usually a certain number of tablets once a week only to avoid GI upsets.