Thank you both MrsD and MelodyL - I do take my B12 on an empty stomach, but my doctor says based on how low my levels are he expected me to require injections for the rest of my life. I don't know what to say about that - they do work. They saved my life. I only started taking oral B12 six months after the injections began (Jan of this year). I always feel MUCH better in the few days following an injection, then my energy slowly trickles away. That's why I was looking for more info. Judging by how my doc thought sub-200 B12 levels were fine you are right - he doesn't know much about B12. Not that I'm blaming him. I'll definitely be taking the methyl B12 now.

MelodyL - do you remember approximately how long you took the methyl B12 before you noticed an improvement?