Originally Posted by mrsD

I've given it up... for now. Hubby is not asking for any either.
He took one 50mcg dose last week.

I've had to go back on my SAMe as my right knee has flared up.
Then my shingles pain came back... so it is 1 gram of Lysine a day. With those two, I am doing quite well actually. The SAMe really helps me with mood and dealing with pain. 400mg is what I am using right now daily. I used SAMe for over a decade while I was still working. I thought my knee was fairly normal so I finally discontinued it. So now I think it might be a lifelong thing for me.