I was (and sometimes) on terrible pain from 2011 to 2013. I could not tolerate the touch of the sheets in my skin, or (literally) anything that touches me even the smoothest materials. I could not stand nor walk for too long. I was miserable, plus I have a whole lot of other major health issues. Anyway, in December 2013, my rheumatologist suggested about the compounded cream. Take note, no one among the 7 neurologists I saw ever mentioned about the existence of such cream. It helps me a lot in my pain. Of course, I am also on several supplements. Aside from my regular supplements, soaking in warm water with epsom salt and applying the epsom lotion at bedtime is part of my daily routine. My cream consists of Ketamine, Baclofen, Clonidine and Gabapentin. Its covered by my insurance.