My aunt actually went to the Mayo clinic for treatment of her pain. I don't know what her actual diagnosis was, but she had severe back pain extending down into her leg, with no known cause. From what I understand, the treatment was unusual but effective-the pain dissolved and never returned. I wish I knew more of the details, but my aunt has brain cancer now and this information is all from her daughter. Maybe someone else has another experience with the Mayo Clinic they can share...all I know is that it did work for my aunt.