Hi Marty,
While medication rotation is sometimes used by doctors and chronic pain patients to help attenuate medication
tolerance; I don't know that it will avert
dependence. Rotation often avoids symptoms of withdrawal by—in effect—swapping one dependence for another, e.g. heroin & methadone.
Quote:
Physical Dependence
Physical dependence is a state of adaptation that is manifested by a drug class specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of the drug, and/or administration of an antagonist.
Tolerance
Tolerance is a state of adaptation in which exposure to a drug induces changes that result in a diminution of one or more of the drug's effects over time.
Definitions Related to the Use of Opioids for the Treatment of Pain: Consensus Statement
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