Hi Kathy! Yes we are at great risk for muscle wasting from lack of use. We must keep moving! Pace your activities. Daily stretching and gentle weight bearing exercisr are essential for maintaing muscle tone. Yes, I get constant muscle twitching that can be maddening. Warm epsom salt bath, heating pad, gentle massage, and sometimes I'll take clonazepam. Muscle relaxants don't seem to do much. Sometimes I also get charley-horse muscle spasm in my calf muscle. Muscle contracts really hard and I have to get up from bed and stand flat footed to end it.