I went gluten-free on my own because of a wide range of inexplicable health problems that worsened in middle age. I was gluten-free for 2 years. Then I did a gluten challenge of 1/2 teaspoon of flour. 2 days later, I had a body-wide flare up of neuropathy (one of my worst symptoms). I told this to my doctor. She had little faith in the Celiac tests. She thought they were unreliable and told me not to bother being tested, just never eat gluten again. So, I would go by symptoms, not tests.