I use Bio-identical hormones. I would suggest you start low and work up. And when first starting estradiol, it apply it in the morning. I put my first patch on at bedtime and woke up in the middle of the night with a slightly racing heart. The nurse told me I should have applied it the morning.

The progesterone has been the most challenging for me. At first, they gave me the oral prometrium. By the third day, the joints in my feet were sore. So I stopped that and switched to a cream. I had to start low and work up to 20 mg/day. My doc wants me at 40 mg/day but it's just too much for me. So right now I'm at 30 mg/day and will be looking to reduce that. I'm finding I more tired in the day at that dose and may be having some joint/tendon issues in my upper back. I've lost some weight and think I need to adjust my dosage. I'll know more after my labs come back. It can take a while to find what will work for you. Don't let them just go by the lab numbers. It's an ongoing balancing act.