Yes, permanent—if there is destruction.

In MG, antibodies attack the muscle receptors. They can block, damage, or destroy them.

http://emedicine.medscape.com/articl...ew#aw2aab6b2b3

http://163.178.103.176/AIBC/Document...ogiadelaMG.pdf

As to whether or not damaged receptors can heal, I have not as yet found a study which confirms that. I'm still looking.

Think of a thousand airline passengers trying to make it through one security checkpoint. That's what our acetylcholine is up against.

Mestinon helps us use the acetylcholine (ACh) longer by blocking the enzyme (acetylcholinesterase) that mops ACh up when it's done making muscle strong. But it does absolutely nothing about the antibody attack.

This is a complex topic, also involving calcium release, muscle fiber size, and so many other details of the neuromuscular junction and muscles.

Scientists can't know for certain how many of our neuromuscular junction muscle receptors are damaged or destroyed. They do guess, though. It might be that those who have more "brittle MG" have more destruction, but, again, only a guessing game.

That's why the clinical presentation is so important in MG. They can't see what our NMJ is up to, but they can see the effects of the antibody attack on our muscles.

What is certain, however, is that the longer you go undiagnosed and untreated, the higher the chance that more of that destruction that can occur.

So the bottom line about your question is that, if you have MG, you need someone to get a grip and help you figure this out!

Hello . . . are there any physicians in the Netherlands who know how to diagnose a patient? Quickly.

Do you know that your country is listed as the fourth happiest in the world? Did they consider healthcare in that equation?


Annie